Emphysema as a Risk Factor for the Outcome of Surgical Resection of Lung Cancer

نویسندگان

  • Sung Ah Lee
  • Joo Sung Sun
  • Joo Hun Park
  • Kyung Joo Park
  • Sung Soo Lee
  • Ho Choi
  • Seung Soo Sheen
  • Woo Young Chung
  • Keu Sung Lee
  • Kwang Joo Park
  • Sung Chul Hwang
چکیده

It is unclear whether emphysema, regardless of airflow limitation, is a predictive factor associated with survival after lung cancer resection. Therefore, we investigated whether emphysema was a risk factor associated with the outcome after resection for lung cancer. This study enrolled 237 patients with non small cell lung cancer with stage I or II who had surgical removal. Patient outcome was analyzed based on emphysema. Emphysema was found in 43.4% of all patients. Patients with emphysema were predominantly men and smokers, and had a lower body mass index than the patients without emphysema. The patients without emphysema (n=133) survived longer (mean 51.2+/-3.0 vs. 40.6+/-3.1 months, P=0.042) than those with emphysema (n=104). The univariate analysis showed a younger age, higher FEV(1)/FVC, higher body mass index, cancer stage I, and a lower emphysema score were significant predictors of better survival. The multivariate analysis revealed a younger age, higher body mass index, and cancer stage I were independent parameters associated with better survival, however, emphysema was not. This study suggests that unfavorable outcomes after surgical resection of lung cancer should not be attributed to emphysema itself.

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عنوان ژورنال:

دوره 25  شماره 

صفحات  -

تاریخ انتشار 2010